Collagen is one of the key elements that keep the skin looking young, firm and smooth. When smiling, squinting, or frowning, we put stress on the underlying collagen in the skin, which results in the development of facial lines. In addition, collagen is depleted naturally while aging. Collagen Replacement Therapy refreshes the skin and makes people look younger. Collagen can be used for worry lines, glabellar lines, periorbital lines, cheek augmentation, nasolabial folds, vermilion border, perioral lines, smile lines, oral commissures, lip augmentation, and chin augmentation.